Bench to Bedside: Modelling Inflammatory Arthritis
نویسندگان
چکیده
Abstract Inflammatory arthritides such as rheumatoid arthritis are a major cause of disability. Pre-clinical murine models inflammatory continue to be invaluable tools with which identify and validate therapeutic targets compounds. The used well-characterised and, whilst none truly recapitulates the human disease, they crucial researchers seeking novel test efficacy during preclinical trials drug candidates. parameters recorded clinical routine patient care have been carefully standardised, allowing comparison between centres, trials, treatments. Similar standardisation scoring across in vivo has not occurred, makes interpretation published results, models, challenging. Here, we include detailed readily implementable system, that increases breadth characteristics captured experimental supports responsive adaptive monitoring disease progression arthritis. In addition, reference wider ethical factors should consider design phase, emphasis on continued importance replacement, reduction, refinement animal usage research.
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ژورنال
عنوان ژورنال: Discovery immunology
سال: 2022
ISSN: ['2754-2483']
DOI: https://doi.org/10.1093/discim/kyac010